Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation

Protein aggregation is a common hallmark of a number of age-related neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and polyglutamine-expansion disorders such as Huntington’s disease, but how aggregation-prone proteins lead to pathology is not known. Using a genome-wide RNAi screen i...

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Detalles Bibliográficos
Autores principales: Teuling, Eva, Bourgonje, Annika, Veenje, Sven, Thijssen, Karen, de Boer, Jelle, van der Velde, Joeri, Swertz, Morris, Nollen, Ellen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Huntington Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166184/
https://www.ncbi.nlm.nih.gov/pubmed/21915392
http://dx.doi.org/10.1371/currents.RRN1255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166184/
https://www.ncbi.nlm.nih.gov/pubmed/21915392
http://dx.doi.org/10.1371/currents.RRN1255

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