Rational Design of Temperature-Sensitive Alleles Using Computational Structure Prediction

Temperature-sensitive (ts) mutations are mutations that exhibit a mutant phenotype at high or low temperatures and a wild-type phenotype at normal temperature. Temperature-sensitive mutants are valuable tools for geneticists, particularly in the study of essential genes. However, finding ts mutation...

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Detalles Bibliográficos
Autores principales: Poultney, Christopher S., Butterfoss, Glenn L., Gutwein, Michelle R., Drew, Kevin, Gresham, David, Gunsalus, Kristin C., Shasha, Dennis E., Bonneau, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166291/
https://www.ncbi.nlm.nih.gov/pubmed/21912654
http://dx.doi.org/10.1371/journal.pone.0023947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166291/
https://www.ncbi.nlm.nih.gov/pubmed/21912654
http://dx.doi.org/10.1371/journal.pone.0023947

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