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Rational Design of Temperature-Sensitive Alleles Using Computational Structure Prediction

Temperature-sensitive (ts) mutations are mutations that exhibit a mutant phenotype at high or low temperatures and a wild-type phenotype at normal temperature. Temperature-sensitive mutants are valuable tools for geneticists, particularly in the study of essential genes. However, finding ts mutation...

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Detalles Bibliográficos
Autores principales:	Poultney, Christopher S., Butterfoss, Glenn L., Gutwein, Michelle R., Drew, Kevin, Gresham, David, Gunsalus, Kristin C., Shasha, Dennis E., Bonneau, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166291/ https://www.ncbi.nlm.nih.gov/pubmed/21912654 http://dx.doi.org/10.1371/journal.pone.0023947

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