Removal of GABA(A) Receptor γ2 Subunits from Parvalbumin Neurons Causes Wide-Ranging Behavioral Alterations

We investigated the behavioral significance of fast synaptic inhibition by αβγ2-type GABA(A) receptors on parvalbumin (Pv) cells. The GABA(A) receptor γ2 subunit gene was selectively inactivated in Pv-positive neurons by Cre/loxP recombination. The resulting Pv-Δγ2 mice were relatively healthy in th...

Descripción completa

Detalles Bibliográficos
Autores principales: Leppä, Elli, Linden, Anni-Maija, Vekovischeva, Olga Y., Swinny, Jerome D., Rantanen, Ville, Toppila, Esko, Höger, Harald, Sieghart, Werner, Wulff, Peer, Wisden, William, Korpi, Esa R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166293/
https://www.ncbi.nlm.nih.gov/pubmed/21912668
http://dx.doi.org/10.1371/journal.pone.0024159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166293/
https://www.ncbi.nlm.nih.gov/pubmed/21912668
http://dx.doi.org/10.1371/journal.pone.0024159

Ejemplares similares