The Stability of a Model Substrate for Topoisomerase 1-Mediated DNA Religation Depends on the Presence of Mismatched Base Pairs

Topoisomerase 1 (Top1) enzymes regulate DNA superhelicity by forming covalent cleavage complexes that undergo controlled rotation. Substitution of nucleoside analogs at the +1 position of the DNA duplex relative to the Top1 cleavage site inhibits DNA religation. The reduced efficiency for Top1-media...

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Detalles Bibliográficos
Autores principales: Gmeiner, William H., Salsbury, Freddie, Olsen, Chris M., Marky, Luis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166759/
https://www.ncbi.nlm.nih.gov/pubmed/21904666
http://dx.doi.org/10.4061/2011/631372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166759/
https://www.ncbi.nlm.nih.gov/pubmed/21904666
http://dx.doi.org/10.4061/2011/631372

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