A Sphingosine Kinase Form 2 Knockout Sensitizes Mouse Myocardium to Ischemia/Reoxygenation Injury and Diminishes Responsiveness to Ischemic Preconditioning

Sphingosine kinase (SphK) exhibits two isoforms, SphK1 and SphK2. Both forms catalyze the synthesis of sphingosine 1-phosphate (S1P), a sphingolipid involved in ischemic preconditioning (IPC). Since the ratio of SphK1 : SphK2 changes dramatically with aging, it is important to assess the role of Sph...

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Detalles Bibliográficos
Autores principales: Vessey, Donald A., Li, Luyi, Jin, Zhu-Qiu, Kelley, Michael, Honbo, Norman, Zhang, Jianqing, Karliner, Joel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166792/
https://www.ncbi.nlm.nih.gov/pubmed/21904650
http://dx.doi.org/10.1155/2011/961059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166792/
https://www.ncbi.nlm.nih.gov/pubmed/21904650
http://dx.doi.org/10.1155/2011/961059

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