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Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis
Heterozygous expression of Nucleophosmin (NPM1) predisposes to hematological malignancies in the mouse and cooperates with Myc in lymphomagenesis. NPM1 is therefore regarded as a haploinsufficient tumor suppressor. Heterozygous loss of NPM1 occurs as a result of the t(2;5) which generates the oncoge...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166849/ https://www.ncbi.nlm.nih.gov/pubmed/21709672 http://dx.doi.org/10.1038/labinvest.2011.96 |