Dual-mode of insulin action controls GLUT4 vesicle exocytosis

Insulin stimulates translocation of GLUT4 storage vesicles (GSVs) to the surface of adipocytes, but precisely where insulin acts is controversial. Here we quantify the size, dynamics, and frequency of single vesicle exocytosis in 3T3-L1 adipocytes. We use a new GSV reporter, VAMP2-pHluorin, and bypa...

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Detalles Bibliográficos
Autores principales: Xu, Yingke, Rubin, Bradley R., Orme, Charisse M., Karpikov, Alexander, Yu, Chenfei, Bogan, Jonathan S., Toomre, Derek K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166865/
https://www.ncbi.nlm.nih.gov/pubmed/21555461
http://dx.doi.org/10.1083/jcb.201008135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166865/
https://www.ncbi.nlm.nih.gov/pubmed/21555461
http://dx.doi.org/10.1083/jcb.201008135

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