Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c

BACKGROUND: High glucose induced lipid synthesis leads to β cell glucolipotoxicity. Sterol regulatory element binding protein-1c (SREBP-1c) is reported to be partially involved in this process. Insulin induced gene-1 (Insig-1) is an important upstream regulator of Insig-1-SREBPs cleavage activating...

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Detalles Bibliográficos
Autores principales: Chen, Ke, jin, ping, He, Hong-hui, Xie, Yan-hong, Xie, Xiao-yun, Mo, Zhao-hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166905/
https://www.ncbi.nlm.nih.gov/pubmed/21843373
http://dx.doi.org/10.1186/1423-0127-18-57

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166905/
https://www.ncbi.nlm.nih.gov/pubmed/21843373
http://dx.doi.org/10.1186/1423-0127-18-57

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