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Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter region

Guanine-rich sequences are highly abundant in the human genome, especially in regulatory regions. Because guanine-rich sequences have the unique ability to form G-quadruplexes, these structures may play a role in the regulation of gene transcription. In previous studies, we demonstrated that formati...

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Detalles Bibliográficos
Autores principales: Onyshchenko, Mykola I., Gaynutdinov, Timur I., Englund, Ethan A., Appella, Daniel H., Neumann, Ronald D., Panyutin, Igor G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167611/
https://www.ncbi.nlm.nih.gov/pubmed/21593130
http://dx.doi.org/10.1093/nar/gkr259