Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery

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The Sleeping Beauty (SB) transposase and its newly developed hyperactive variant, SB100X, are of increasing interest for genome modification in experimental models and gene therapy. The potential cytotoxicity of transposases requires careful assessment, considering that residual integration events o...

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Detalles Bibliográficos
Autores principales: Galla, Melanie, Schambach, Axel, Falk, Christine S., Maetzig, Tobias, Kuehle, Johannes, Lange, Kathrin, Zychlinski, Daniela, Heinz, Niels, Brugman, Martijn H., Göhring, Gudrun, Izsvák, Zsuzsanna, Ivics, Zoltán, Baum, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167617/
https://www.ncbi.nlm.nih.gov/pubmed/21609958
http://dx.doi.org/10.1093/nar/gkr384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167617/
https://www.ncbi.nlm.nih.gov/pubmed/21609958
http://dx.doi.org/10.1093/nar/gkr384

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