A novel screening system improves genetic correction by internal exon replacement

Trans-splicing is a powerful approach to reprogram the genome. It can be used to replace 5′, 3′ or internal exons. The latter approach has been characterized by low efficiency, as the requirements to promote internal trans-splicing are largely uncharacterized. The trans-splicing process is induced b...

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Detalles Bibliográficos
Autores principales: Koller, Ulrich, Wally, Verena, Mitchell, Lloyd G., Klausegger, Alfred, Murauer, Eva M., Mayr, Elisabeth, Gruber, Christina, Hainzl, Stefan, Hintner, Helmut, Bauer, Johann W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167625/
https://www.ncbi.nlm.nih.gov/pubmed/21685452
http://dx.doi.org/10.1093/nar/gkr465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167625/
https://www.ncbi.nlm.nih.gov/pubmed/21685452
http://dx.doi.org/10.1093/nar/gkr465

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