Phosphorylation of Mcm2 modulates Mcm2–7 activity and affects the cell’s response to DNA damage

The S-phase kinase, DDK controls DNA replication through phosphorylation of the replicative helicase, Mcm2–7. We show that phosphorylation of Mcm2 at S164 and S170 is not essential for viability. However, the relevance of Mcm2 phosphorylation is demonstrated by the sensitivity of a strain containing...

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Detalles Bibliográficos
Autores principales: Stead, Brent E., Brandl, Christopher J., Davey, Megan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167627/
https://www.ncbi.nlm.nih.gov/pubmed/21596784
http://dx.doi.org/10.1093/nar/gkr371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167627/
https://www.ncbi.nlm.nih.gov/pubmed/21596784
http://dx.doi.org/10.1093/nar/gkr371

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