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Phosphorylation of Mcm2 modulates Mcm2–7 activity and affects the cell’s response to DNA damage
The S-phase kinase, DDK controls DNA replication through phosphorylation of the replicative helicase, Mcm2–7. We show that phosphorylation of Mcm2 at S164 and S170 is not essential for viability. However, the relevance of Mcm2 phosphorylation is demonstrated by the sensitivity of a strain containing...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167627/ https://www.ncbi.nlm.nih.gov/pubmed/21596784 http://dx.doi.org/10.1093/nar/gkr371 |