Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase

Avian influenza A viruses often do not propagate efficiently in mammalian cells. The viral polymerase protein PB2 is important for this host restriction, with amino-acid polymorphisms at residue 627 and other positions acting as ‘signatures’ of avian- or human-adapted viruses. Restriction is hypothe...

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Detalles Bibliográficos
Autores principales: Foeglein, Ágnes, Loucaides, Eva M., Mura, Manuela, Wise, Helen M., Barclay, Wendy S., Digard, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for General Microbiology 2011
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167894/
https://www.ncbi.nlm.nih.gov/pubmed/21471313
http://dx.doi.org/10.1099/vir.0.031492-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167894/
https://www.ncbi.nlm.nih.gov/pubmed/21471313
http://dx.doi.org/10.1099/vir.0.031492-0

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