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Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase
Avian influenza A viruses often do not propagate efficiently in mammalian cells. The viral polymerase protein PB2 is important for this host restriction, with amino-acid polymorphisms at residue 627 and other positions acting as ‘signatures’ of avian- or human-adapted viruses. Restriction is hypothe...
Autores principales: | Foeglein, Ágnes, Loucaides, Eva M., Mura, Manuela, Wise, Helen M., Barclay, Wendy S., Digard, Paul |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for General Microbiology
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167894/ https://www.ncbi.nlm.nih.gov/pubmed/21471313 http://dx.doi.org/10.1099/vir.0.031492-0 |
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