Drosophila KCNQ Channel Displays Evolutionarily Conserved Electrophysiology and Pharmacology with Mammalian KCNQ Channels

Of the five human KCNQ (Kv7) channels, KCNQ1 with auxiliary subunit KCNE1 mediates the native cardiac I(Ks) current with mutations causing short and long QT cardiac arrhythmias. KCNQ4 mutations cause deafness. KCNQ2/3 channels form the native M-current controlling excitability of most neurons, with...

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Detalles Bibliográficos
Autores principales: Cavaliere, Sonia, Hodge, James J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168433/
https://www.ncbi.nlm.nih.gov/pubmed/21915266
http://dx.doi.org/10.1371/journal.pone.0023898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168433/
https://www.ncbi.nlm.nih.gov/pubmed/21915266
http://dx.doi.org/10.1371/journal.pone.0023898

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