Transgenic Expression of Human LAMA5 Suppresses Murine Lama5 mRNA and Laminin α5 Protein Deposition

Laminin α5 is required for kidney glomerular basement membrane (GBM) assembly, and mice with targeted deletions of the Lama5 gene fail to form glomeruli. As a tool to begin to understand factors regulating the expression of the LAMA5 gene, we generated transgenic mice carrying the human LAMA5 locus...

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Detalles Bibliográficos
Autores principales: Steenhard, Brooke M., Zelenchuk, Adrian, Stroganova, Larysa, Isom, Kathryn, St. John, Patricia L., Andrews, Glen K., Peterson, Kenneth R., Abrahamson, Dale R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168496/
https://www.ncbi.nlm.nih.gov/pubmed/21915268
http://dx.doi.org/10.1371/journal.pone.0023926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168496/
https://www.ncbi.nlm.nih.gov/pubmed/21915268
http://dx.doi.org/10.1371/journal.pone.0023926

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