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Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

Alzheimer's disease (AD) is pathologically characterised by the age-dependent deposition of β-amyloid (Aβ) in senile plaques, intraneuronal accumulation of tau as neurofibrillary tangles, synaptic dysfunction and neuronal death. Neuroinflammation, typified by the accumulation of activated micro...

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Detalles Bibliográficos
Autores principales: Garwood, C J, Pooler, A M, Atherton, J, Hanger, D P, Noble, W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168992/
https://www.ncbi.nlm.nih.gov/pubmed/21633390
http://dx.doi.org/10.1038/cddis.2011.50