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The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance
Three-dimensional (3D) cultures are a valuable platform to study acquired multicellular apoptotic resistance of cancer. We used spheroids of cell lines and actual tumor to study resistance to the proteasome inhibitor bortezomib in mesothelioma, a highly chemoresistant tumor. Spheroids from mesotheli...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169000/ https://www.ncbi.nlm.nih.gov/pubmed/21697949 http://dx.doi.org/10.1038/cddis.2011.58 |