Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening

Glutaric acidemia type 1 is an inherited metabolic disorder which can cause macrocephaly, muscular rigidity, spastic paralysis and other progressive movement disorders in humans. The defects in glutaryl-CoA dehydrogenase (GCDH) associated with this disease are thought to increase holoenzyme instabil...

Descripción completa

Detalles Bibliográficos
Autores principales: Begley, Darren W., Davies, Douglas R., Hartley, Robert C., Hewitt, Stephen N., Rychel, Amanda L., Myler, Peter J., Van Voorhis, Wesley C., Staker, Bart L., Stewart, Lance J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Structural Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169403/
https://www.ncbi.nlm.nih.gov/pubmed/21904051
http://dx.doi.org/10.1107/S1744309111014436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169403/
https://www.ncbi.nlm.nih.gov/pubmed/21904051
http://dx.doi.org/10.1107/S1744309111014436

Ejemplares similares