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Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening

Glutaric acidemia type 1 is an inherited metabolic disorder which can cause macrocephaly, muscular rigidity, spastic paralysis and other progressive movement disorders in humans. The defects in glutaryl-CoA dehydrogenase (GCDH) associated with this disease are thought to increase holoenzyme instabil...

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Detalles Bibliográficos
Autores principales:	Begley, Darren W., Davies, Douglas R., Hartley, Robert C., Hewitt, Stephen N., Rychel, Amanda L., Myler, Peter J., Van Voorhis, Wesley C., Staker, Bart L., Stewart, Lance J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2011
Materias:	Structural Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169403/ https://www.ncbi.nlm.nih.gov/pubmed/21904051 http://dx.doi.org/10.1107/S1744309111014436

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