High-level inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal

BACKGROUND: The activities of mitochondrial complex III (ubiquinol-cytochrome c reductase, EC 1.10.2.2) and complex IV (cytochrome c oxidase EC 1.9.3.1) are reduced by 30-70% in Huntington's disease and Alzheimer's disease, respectively, and are associated with excitotoxic cell death in th...

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Detalles Bibliográficos
Autores principales: Kilbride, Seán M, Gluchowska, Sonia A, Telford, Jayne E, O'Sullivan, Catherine, Davey, Gavin P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169489/
https://www.ncbi.nlm.nih.gov/pubmed/21791084
http://dx.doi.org/10.1186/1750-1326-6-53

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169489/
https://www.ncbi.nlm.nih.gov/pubmed/21791084
http://dx.doi.org/10.1186/1750-1326-6-53

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