Structured Pathway across the Transition State for Peptide Folding Revealed by Molecular Dynamics Simulations

Small globular proteins and peptides commonly exhibit two-state folding kinetics in which the rate limiting step of folding is the surmounting of a single free energy barrier at the transition state (TS) separating the folded and the unfolded states. An intriguing question is whether the polypeptide...

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Detalles Bibliográficos
Autores principales: Thukral, Lipi, Daidone, Isabella, Smith, Jeremy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169518/
https://www.ncbi.nlm.nih.gov/pubmed/21931542
http://dx.doi.org/10.1371/journal.pcbi.1002137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169518/
https://www.ncbi.nlm.nih.gov/pubmed/21931542
http://dx.doi.org/10.1371/journal.pcbi.1002137

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