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Structured Pathway across the Transition State for Peptide Folding Revealed by Molecular Dynamics Simulations
Small globular proteins and peptides commonly exhibit two-state folding kinetics in which the rate limiting step of folding is the surmounting of a single free energy barrier at the transition state (TS) separating the folded and the unfolded states. An intriguing question is whether the polypeptide...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169518/ https://www.ncbi.nlm.nih.gov/pubmed/21931542 http://dx.doi.org/10.1371/journal.pcbi.1002137 |