Toxoplasma gondii Rhoptry Kinase ROP16 Activates STAT3 and STAT6 Resulting in Cytokine Inhibition and Arginase-1-Dependent Growth Control

The ROP16 kinase of Toxoplasma gondii is injected into the host cell cytosol where it activates signal transducer and activator of transcription (STAT)-3 and STAT6. Here, we generated a ROP16 deletion mutant on a Type I parasite strain background, as well as a control complementation mutant with res...

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Detalles Bibliográficos
Autores principales: Butcher, Barbara A., Fox, Barbara A., Rommereim, Leah M., Kim, Sung Guk, Maurer, Kirk J., Yarovinsky, Felix, Herbert, De'Broski R., Bzik, David J., Denkers, Eric Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169547/
https://www.ncbi.nlm.nih.gov/pubmed/21931552
http://dx.doi.org/10.1371/journal.ppat.1002236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169547/
https://www.ncbi.nlm.nih.gov/pubmed/21931552
http://dx.doi.org/10.1371/journal.ppat.1002236

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