Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7

Recognition of viruses by pattern recognition receptors (PRRs) causes interferon-β (IFN-β) induction, a key event in the anti-viral innate immune response, and also a target of viral immune evasion. Here the vaccinia virus (VACV) protein C6 is identified as an inhibitor of PRR-induced IFN-β expressi...

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Detalles Bibliográficos
Autores principales: Unterholzner, Leonie, Sumner, Rebecca P., Baran, Marcin, Ren, Hongwei, Mansur, Daniel S., Bourke, Nollaig M., Randow, Felix, Smith, Geoffrey L., Bowie, Andrew G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169548/
https://www.ncbi.nlm.nih.gov/pubmed/21931555
http://dx.doi.org/10.1371/journal.ppat.1002247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169548/
https://www.ncbi.nlm.nih.gov/pubmed/21931555
http://dx.doi.org/10.1371/journal.ppat.1002247

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