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The Human Endogenous Circadian System Causes Greatest Platelet Activation during the Biological Morning Independent of Behaviors

BACKGROUND: Platelets are involved in the thromboses that are central to myocardial infarctions and ischemic strokes. Such adverse cardiovascular events have day/night patterns with peaks in the morning (∼9AM), potentially related to endogenous circadian clock control of platelet activation. The obj...

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Autores principales: Scheer, Frank A. J. L., Michelson, Alan D., Frelinger, Andrew L., Evoniuk, Heather, Kelly, Erin E., McCarthy, Mary, Doamekpor, Lauren A., Barnard, Marc R., Shea, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169622/
https://www.ncbi.nlm.nih.gov/pubmed/21931750
http://dx.doi.org/10.1371/journal.pone.0024549
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author Scheer, Frank A. J. L.
Michelson, Alan D.
Frelinger, Andrew L.
Evoniuk, Heather
Kelly, Erin E.
McCarthy, Mary
Doamekpor, Lauren A.
Barnard, Marc R.
Shea, Steven A.
author_facet Scheer, Frank A. J. L.
Michelson, Alan D.
Frelinger, Andrew L.
Evoniuk, Heather
Kelly, Erin E.
McCarthy, Mary
Doamekpor, Lauren A.
Barnard, Marc R.
Shea, Steven A.
author_sort Scheer, Frank A. J. L.
collection PubMed
description BACKGROUND: Platelets are involved in the thromboses that are central to myocardial infarctions and ischemic strokes. Such adverse cardiovascular events have day/night patterns with peaks in the morning (∼9AM), potentially related to endogenous circadian clock control of platelet activation. The objective was to test if the human endogenous circadian system influences (1) platelet function and (2) platelet response to standardized behavioral stressors. We also aimed to compare the magnitude of any effects on platelet function caused by the circadian system with that caused by varied standardized behavioral stressors, including mental arithmetic, passive postural tilt and mild cycling exercise. METHODOLOGY/PRINCIPAL FINDINGS: We studied 12 healthy adults (6 female) who lived in individual laboratory suites in dim light for 240 h, with all behaviors scheduled on a 20-h recurring cycle to permit assessment of endogenous circadian function independent from environmental and behavioral effects including the sleep/wake cycle. Circadian phase was assessed from core body temperature. There were highly significant endogenous circadian rhythms in platelet surface activated glycoprotein (GP) IIb-IIIa, GPIb and P-selectin (6–17% peak-trough amplitudes; p≤0.01). These circadian peaks occurred at a circadian phase corresponding to 8–9AM. Platelet count, ATP release, aggregability, and plasma epinephrine also had significant circadian rhythms but with later peaks (corresponding to 3–8PM). The circadian effects on the platelet activation markers were always larger than that of any of the three behavioral stressors. CONCLUSIONS/SIGNIFICANCE: These data demonstrate robust effects of the endogenous circadian system on platelet activation in humans—independent of the sleep/wake cycle, other behavioral influences and the environment. The ∼9AM timing of the circadian peaks of the three platelet surface markers, including platelet surface activated GPIIb-IIIa, the final common pathway of platelet aggregation, suggests that endogenous circadian influences on platelet function could contribute to the morning peak in adverse cardiovascular events as seen in many epidemiological studies.
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spelling pubmed-31696222011-09-19 The Human Endogenous Circadian System Causes Greatest Platelet Activation during the Biological Morning Independent of Behaviors Scheer, Frank A. J. L. Michelson, Alan D. Frelinger, Andrew L. Evoniuk, Heather Kelly, Erin E. McCarthy, Mary Doamekpor, Lauren A. Barnard, Marc R. Shea, Steven A. PLoS One Research Article BACKGROUND: Platelets are involved in the thromboses that are central to myocardial infarctions and ischemic strokes. Such adverse cardiovascular events have day/night patterns with peaks in the morning (∼9AM), potentially related to endogenous circadian clock control of platelet activation. The objective was to test if the human endogenous circadian system influences (1) platelet function and (2) platelet response to standardized behavioral stressors. We also aimed to compare the magnitude of any effects on platelet function caused by the circadian system with that caused by varied standardized behavioral stressors, including mental arithmetic, passive postural tilt and mild cycling exercise. METHODOLOGY/PRINCIPAL FINDINGS: We studied 12 healthy adults (6 female) who lived in individual laboratory suites in dim light for 240 h, with all behaviors scheduled on a 20-h recurring cycle to permit assessment of endogenous circadian function independent from environmental and behavioral effects including the sleep/wake cycle. Circadian phase was assessed from core body temperature. There were highly significant endogenous circadian rhythms in platelet surface activated glycoprotein (GP) IIb-IIIa, GPIb and P-selectin (6–17% peak-trough amplitudes; p≤0.01). These circadian peaks occurred at a circadian phase corresponding to 8–9AM. Platelet count, ATP release, aggregability, and plasma epinephrine also had significant circadian rhythms but with later peaks (corresponding to 3–8PM). The circadian effects on the platelet activation markers were always larger than that of any of the three behavioral stressors. CONCLUSIONS/SIGNIFICANCE: These data demonstrate robust effects of the endogenous circadian system on platelet activation in humans—independent of the sleep/wake cycle, other behavioral influences and the environment. The ∼9AM timing of the circadian peaks of the three platelet surface markers, including platelet surface activated GPIIb-IIIa, the final common pathway of platelet aggregation, suggests that endogenous circadian influences on platelet function could contribute to the morning peak in adverse cardiovascular events as seen in many epidemiological studies. Public Library of Science 2011-09-08 /pmc/articles/PMC3169622/ /pubmed/21931750 http://dx.doi.org/10.1371/journal.pone.0024549 Text en Scheer et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Scheer, Frank A. J. L.
Michelson, Alan D.
Frelinger, Andrew L.
Evoniuk, Heather
Kelly, Erin E.
McCarthy, Mary
Doamekpor, Lauren A.
Barnard, Marc R.
Shea, Steven A.
The Human Endogenous Circadian System Causes Greatest Platelet Activation during the Biological Morning Independent of Behaviors
title The Human Endogenous Circadian System Causes Greatest Platelet Activation during the Biological Morning Independent of Behaviors
title_full The Human Endogenous Circadian System Causes Greatest Platelet Activation during the Biological Morning Independent of Behaviors
title_fullStr The Human Endogenous Circadian System Causes Greatest Platelet Activation during the Biological Morning Independent of Behaviors
title_full_unstemmed The Human Endogenous Circadian System Causes Greatest Platelet Activation during the Biological Morning Independent of Behaviors
title_short The Human Endogenous Circadian System Causes Greatest Platelet Activation during the Biological Morning Independent of Behaviors
title_sort human endogenous circadian system causes greatest platelet activation during the biological morning independent of behaviors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169622/
https://www.ncbi.nlm.nih.gov/pubmed/21931750
http://dx.doi.org/10.1371/journal.pone.0024549
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