Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and -independent mechanisms

PIK3CA gain-of-function mutations are a common oncogenic event in human malignancy(1–4), making PI3K an attractive target for cancer therapy. Despite the great promise of targeted therapy, resistance often develops, resulting in treatment failure. To elucidate mechanisms of resistance to PI3K-target...

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Detalles Bibliográficos
Autores principales: Liu, Pixu, Cheng, Hailing, Santiago, Stephanie, Raeder, Maria, Zhang, Fan, Isabella, Adam, Yang, Janet, Semaan, Derek J., Chen, Changzhong, Fox, Edward A., Gray, Nathanael S., Monahan, John, Schlegel, Robert, Beroukhim, Rameen, Mills, Gordon B., Zhao, Jean J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169724/
https://www.ncbi.nlm.nih.gov/pubmed/21822287
http://dx.doi.org/10.1038/nm.2402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169724/
https://www.ncbi.nlm.nih.gov/pubmed/21822287
http://dx.doi.org/10.1038/nm.2402

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