Macitentan: entry-into-humans study with a new endothelin receptor antagonist

PURPOSE: To study the pharmacokinetics, pharmacodynamics, and tolerability of rising single doses of macitentan, an endothelin receptor antagonist, in healthy male subjects. METHODS: This double-blind, placebo-controlled study was performed in seven groups of eight healthy male subjects. Doses of 0....

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Detalles Bibliográficos
Autores principales: Sidharta, Patricia N., van Giersbergen, Paul L. M., Halabi, Atef, Dingemanse, Jasper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Clinical Trial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169777/
https://www.ncbi.nlm.nih.gov/pubmed/21541781
http://dx.doi.org/10.1007/s00228-011-1043-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169777/
https://www.ncbi.nlm.nih.gov/pubmed/21541781
http://dx.doi.org/10.1007/s00228-011-1043-2

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