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Conformational selection or induced fit? 50 years of debate resolved

Exactly 50 years ago, biochemists raised the question of the mechanism of the conformational change that mediates “allosteric” interactions between regulatory sites and biologically active sites in regulatory/receptor proteins. Do the different conformations involved already exist spontaneously in t...

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Detalles Bibliográficos
Autores principales: Changeux, Jean-Pierre, Edelstein, Stuart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169905/
https://www.ncbi.nlm.nih.gov/pubmed/21941598
http://dx.doi.org/10.3410/B3-19