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Sympathetic nervous dysregulation in the absence of systolic left ventricular dysfunction in a rat model of insulin resistance with hyperglycemia

BACKGROUND: Diabetes mellitus is strongly associated with cardiovascular dysfunction, derived in part from impairment of sympathetic nervous system signaling. Glucose, insulin, and non-esterified fatty acids are potent stimulants of sympathetic activity and norepinephrine (NE) release. We hypothesiz...

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Detalles Bibliográficos
Autores principales: Thackeray, James T, Radziuk, Jerry, Harper, Mary-Ellen, Suuronen, Erik J, Ascah, Kathryn J, Beanlands, Rob S, DaSilva, Jean N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170183/
https://www.ncbi.nlm.nih.gov/pubmed/21831292
http://dx.doi.org/10.1186/1475-2840-10-75