Hypoxia Inhibits Osteogenesis in Human Mesenchymal Stem Cells through Direct Regulation of RUNX2 by TWIST

BACKGROUND: Bone loss induced by hypoxia is associated with various pathophysiological conditions, however, little is known about the effects of hypoxia and related signaling pathways on osteoblast differentiation and bone formation. Because bone marrow-derived mesenchymal stem cells (MSCs) survive...

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Detalles Bibliográficos
Autores principales: Yang, Der-Chih, Yang, Muh-Hwa, Tsai, Chih-Chien, Huang, Tung-Fu, Chen, Yau-Hung, Hung, Shih-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170288/
https://www.ncbi.nlm.nih.gov/pubmed/21931630
http://dx.doi.org/10.1371/journal.pone.0023965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170288/
https://www.ncbi.nlm.nih.gov/pubmed/21931630
http://dx.doi.org/10.1371/journal.pone.0023965

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