Lithium Suppresses Astrogliogenesis by Neural Stem and Progenitor Cells by Inhibiting STAT3 Pathway Independently of Glycogen Synthase Kinase 3 Beta

Transplanted neural stem and progenitor cells (NSCs) produce mostly astrocytes in injured spinal cords. Lithium stimulates neurogenesis by inhibiting GSK3b (glycogen synthetase kinase 3-beta) and increasing WNT/beta catenin. Lithium suppresses astrogliogenesis but the mechanisms were unclear. We cul...

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Detalles Bibliográficos
Autores principales: Zhu, Zhenzhong, Kremer, Penny, Tadmori, Iman, Ren, Yi, Sun, Dongming, He, Xijing, Young, Wise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170293/
https://www.ncbi.nlm.nih.gov/pubmed/21931595
http://dx.doi.org/10.1371/journal.pone.0023341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170293/
https://www.ncbi.nlm.nih.gov/pubmed/21931595
http://dx.doi.org/10.1371/journal.pone.0023341

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