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Therapeutic promise and challenges of targeting DLL4/NOTCH1

DLL4-mediated NOTCH1 signaling represents an essential pathway for vascular development and has emerged as an attractive target for angiogenesis-based cancer therapies. However, newly reported toxicity findings raise safety concerns of chronic pathway blockade. Lessons learned from the development o...

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Detalles Bibliográficos
Autor principal: Yan, Minhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170613/
https://www.ncbi.nlm.nih.gov/pubmed/21824400
http://dx.doi.org/10.1186/2045-824X-3-17