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Therapeutic promise and challenges of targeting DLL4/NOTCH1
DLL4-mediated NOTCH1 signaling represents an essential pathway for vascular development and has emerged as an attractive target for angiogenesis-based cancer therapies. However, newly reported toxicity findings raise safety concerns of chronic pathway blockade. Lessons learned from the development o...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170613/ https://www.ncbi.nlm.nih.gov/pubmed/21824400 http://dx.doi.org/10.1186/2045-824X-3-17 |