Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?

SUMMARY: Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene strongly predispose to development of gastro-intestinal tumors. Central to the tumorigenic events in APC mutant cells is the uncontrolled stabilization and transcriptional activation of the protein β-catenin. Many quest...

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Detalles Bibliográficos
Autores principales: Minde, David P, Anvarian, Zeinab, Rüdiger, Stefan GD, Maurice, Madelon M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170638/
https://www.ncbi.nlm.nih.gov/pubmed/21859464
http://dx.doi.org/10.1186/1476-4598-10-101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170638/
https://www.ncbi.nlm.nih.gov/pubmed/21859464
http://dx.doi.org/10.1186/1476-4598-10-101

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