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Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?
SUMMARY: Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene strongly predispose to development of gastro-intestinal tumors. Central to the tumorigenic events in APC mutant cells is the uncontrolled stabilization and transcriptional activation of the protein β-catenin. Many quest...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170638/ https://www.ncbi.nlm.nih.gov/pubmed/21859464 http://dx.doi.org/10.1186/1476-4598-10-101 |