Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors

BACKGROUND: Betulinic acid (BA) inhibits growth of several cancer cell lines and tumors and the effects of BA have been attributed to its mitochondriotoxicity and inhibition of multiple pro-oncogenic factors. Previous studies show that BA induces proteasome-dependent degradation of specificity prote...

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Detalles Bibliográficos
Autores principales: Chintharlapalli, Sudhakar, Papineni, Sabitha, Lei, Ping, Pathi, Satya, Safe, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170653/
https://www.ncbi.nlm.nih.gov/pubmed/21864401
http://dx.doi.org/10.1186/1471-2407-11-371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170653/
https://www.ncbi.nlm.nih.gov/pubmed/21864401
http://dx.doi.org/10.1186/1471-2407-11-371

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