Apoptosis Modulation as a Promising Target for Treatment of Systemic Sclerosis

Diffuse systemic sclerosis (SSc) is a fatal autoimmune disease characterized by an excessive ECM deposition inducing a loss of function of skin and internal organs. Apoptosis is a key mechanism involved in all the stages of the disease: vascular damage, immune dysfunction, and fibrosis. The purpose...

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Detalles Bibliográficos
Autores principales: Chabaud, Stéphane, Moulin, Véronique J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170778/
https://www.ncbi.nlm.nih.gov/pubmed/21912551
http://dx.doi.org/10.1155/2011/495792
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author Chabaud, Stéphane
Moulin, Véronique J.
author_facet Chabaud, Stéphane
Moulin, Véronique J.
author_sort Chabaud, Stéphane
collection PubMed
description Diffuse systemic sclerosis (SSc) is a fatal autoimmune disease characterized by an excessive ECM deposition inducing a loss of function of skin and internal organs. Apoptosis is a key mechanism involved in all the stages of the disease: vascular damage, immune dysfunction, and fibrosis. The purpose of this paper is to gather new findings in apoptosis related to SSc, to highlight relations between apoptosis and fibrosis, and to identify new therapeutic targets.
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spelling pubmed-31707782011-09-12 Apoptosis Modulation as a Promising Target for Treatment of Systemic Sclerosis Chabaud, Stéphane Moulin, Véronique J. Int J Rheumatol Review Article Diffuse systemic sclerosis (SSc) is a fatal autoimmune disease characterized by an excessive ECM deposition inducing a loss of function of skin and internal organs. Apoptosis is a key mechanism involved in all the stages of the disease: vascular damage, immune dysfunction, and fibrosis. The purpose of this paper is to gather new findings in apoptosis related to SSc, to highlight relations between apoptosis and fibrosis, and to identify new therapeutic targets. Hindawi Publishing Corporation 2011 2011-09-06 /pmc/articles/PMC3170778/ /pubmed/21912551 http://dx.doi.org/10.1155/2011/495792 Text en Copyright © 2011 S. Chabaud and V. J. Moulin. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chabaud, Stéphane
Moulin, Véronique J.
Apoptosis Modulation as a Promising Target for Treatment of Systemic Sclerosis
title Apoptosis Modulation as a Promising Target for Treatment of Systemic Sclerosis
title_full Apoptosis Modulation as a Promising Target for Treatment of Systemic Sclerosis
title_fullStr Apoptosis Modulation as a Promising Target for Treatment of Systemic Sclerosis
title_full_unstemmed Apoptosis Modulation as a Promising Target for Treatment of Systemic Sclerosis
title_short Apoptosis Modulation as a Promising Target for Treatment of Systemic Sclerosis
title_sort apoptosis modulation as a promising target for treatment of systemic sclerosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170778/
https://www.ncbi.nlm.nih.gov/pubmed/21912551
http://dx.doi.org/10.1155/2011/495792
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