Dual AAV/IL-10 Plus STAT3 Anti-Inflammatory Gene Delivery Lowers Atherosclerosis in LDLR KO Mice, but without Increased Benefit

Both IL-10 and STAT3 are in the same signal transduction pathway, with IL-10-bound IL10 receptor (R) acting through STAT3 for anti-inflammatory effect. To investigate possible therapeutic synergism, we delivered both full-length wild-type human (h) STAT3 and hIL-10 genes by separate adenoassociated...

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Detalles Bibliográficos
Autores principales: Cao, Maohua, Khan, Junaid A., Kang, Bum-Yong, Mehta, Jawahar L., Hermonat, Paul L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170890/
https://www.ncbi.nlm.nih.gov/pubmed/21915378
http://dx.doi.org/10.1155/2012/524235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170890/
https://www.ncbi.nlm.nih.gov/pubmed/21915378
http://dx.doi.org/10.1155/2012/524235

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