Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours

BACKGROUND: Immunodeficiency in ataxia telangiectasia (A-T) is less severe in patients expressing some mutant or normal ATM kinase activity. We, therefore, determined whether expression of residual ATM kinase activity also protected against tumour development in A-T. METHODS: From a total of 296 con...

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Detalles Bibliográficos
Autores principales: Reiman, A, Srinivasan, V, Barone, G, Last, J I, Wootton, L L, Davies, E G, Verhagen, M M, Willemsen, M A, Weemaes, C M, Byrd, P J, Izatt, L, Easton, D F, Thompson, D J, Taylor, A M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170966/
https://www.ncbi.nlm.nih.gov/pubmed/21792198
http://dx.doi.org/10.1038/bjc.2011.266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170966/
https://www.ncbi.nlm.nih.gov/pubmed/21792198
http://dx.doi.org/10.1038/bjc.2011.266

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