Loss of Roquin induces early death and immune deregulation but not autoimmunity

The substitution of one amino acid in the Roquin protein by the sanroque mutation induces a dramatic autoimmune syndrome in mice. This is believed to occur through ectopic expression of inducible T cell co-stimulator (ICOS) and unrestrained differentiation of follicular T helper cells, which induce...

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Detalles Bibliográficos
Autores principales: Bertossi, Arianna, Aichinger, Martin, Sansonetti, Paola, Lech, Maciej, Neff, Frauke, Pal, Martin, Wunderlich, F. Thomas, Anders, Hans-Joachim, Klein, Ludger, Schmidt-Supprian, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171092/
https://www.ncbi.nlm.nih.gov/pubmed/21844204
http://dx.doi.org/10.1084/jem.20110578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171092/
https://www.ncbi.nlm.nih.gov/pubmed/21844204
http://dx.doi.org/10.1084/jem.20110578

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