High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer of immature T cells that often shows aberrant activation of Notch1 and PI3K–Akt pathways. Although mutations that activate PI3K–Akt signaling have previously been identified, the relative contribution of growth factor-dependent acti...

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Detalles Bibliográficos
Autores principales: Medyouf, Hind, Gusscott, Samuel, Wang, Hongfang, Tseng, Jen-Chieh, Wai, Carol, Nemirovsky, Oksana, Trumpp, Andreas, Pflumio, Francoise, Carboni, Joan, Gottardis, Marco, Pollak, Michael, Kung, Andrew L., Aster, Jon C., Holzenberger, Martin, Weng, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171095/
https://www.ncbi.nlm.nih.gov/pubmed/21807868
http://dx.doi.org/10.1084/jem.20110121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171095/
https://www.ncbi.nlm.nih.gov/pubmed/21807868
http://dx.doi.org/10.1084/jem.20110121

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