Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair

DNA double-strand break (DSB) resection, which results in RPA-bound single-stranded DNA (ssDNA), is activated in S phase by Cdk2. RPA-ssDNA activates the ATR-dependent checkpoint and homology-directed repair (HDR) via Rad51-dependent mechanisms. On the other hand, the fate of DSBs sustained during v...

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Detalles Bibliográficos
Autores principales: Peterson, Shaun E., Li, Yinyin, Chait, Brian T., Gottesman, Max E., Baer, Richard, Gautier, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171114/
https://www.ncbi.nlm.nih.gov/pubmed/21893598
http://dx.doi.org/10.1083/jcb.201103103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171114/
https://www.ncbi.nlm.nih.gov/pubmed/21893598
http://dx.doi.org/10.1083/jcb.201103103

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