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Genetic Risk Score Predicting Risk of Rheumatoid Arthritis Phenotypes and Age of Symptom Onset

BACKGROUND: Cumulative genetic profiles can help identify individuals at high-risk for developing RA. We examined the impact of 39 validated genetic risk alleles on the risk of RA phenotypes characterized by serologic and erosive status. METHODS/PRINCIPAL FINDINGS: We evaluated single nucleotide pol...

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Detalles Bibliográficos
Autores principales: Chibnik, Lori B., Keenan, Brendan T., Cui, Jing, Liao, Katherine P., Costenbader, Karen H., Plenge, Robert M., Karlson, Elizabeth W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171415/
https://www.ncbi.nlm.nih.gov/pubmed/21931699
http://dx.doi.org/10.1371/journal.pone.0024380