Cargando…

D-β-Hydroxybutyrate Is Protective in Mouse Models of Huntington's Disease

Abnormalities in mitochondrial function and epigenetic regulation are thought to be instrumental in Huntington's disease (HD), a fatal genetic disorder caused by an expanded polyglutamine track in the protein huntingtin. Given the lack of effective therapies for HD, we sought to assess the neur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lim, Soyeon, Chesser, Adrianne S., Grima, Jonathan C., Rappold, Phillip M., Blum, David, Przedborski, Serge, Tieu, Kim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171454/ https://www.ncbi.nlm.nih.gov/pubmed/21931779 http://dx.doi.org/10.1371/journal.pone.0024620

Ejemplares similares

Why a d-β-hydroxybutyrate monoester?
por: Soto-Mota, Adrian, et al.
Publicado: (2020)

On the nutritional and therapeutic effects of ketone body d-β-hydroxybutyrate
por: Yao, Aliya, et al.
Publicado: (2021)

The action of β-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours: evidence of a β-hydroxybutyrate paradox
por: Rodrigues, Loreta M., et al.
Publicado: (2017)

Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease
por: Dedkova, Elena N., et al.
Publicado: (2014)

Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo
por: Rappold, Phillip M., et al.
Publicado: (2014)

Anticonvulsant Effects of β-Hydroxybutyrate in Mice
por: Yum, Mi-Sun, et al.
Publicado: (2012)

β-hydroxybutyrate as an Anti-Aging Metabolite
por: Wang, Lian, et al.
Publicado: (2021)

Proanthocyanidins Protect against β-Hydroxybutyrate-Induced Oxidative Damage in Bovine Endometrial Cells
por: Cheng, Xi, et al.
Publicado: (2019)

Virulence-inhibitory activity of the degradation product 3-hydroxybutyrate explains the protective effect of poly-β-hydroxybutyrate against the major aquaculture pathogen Vibrio campbellii
por: Defoirdt, Tom, et al.
Publicado: (2018)

In vitro human colonic microbiota utilises D-β-hydroxybutyrate to increase butyrogenesis
por: Sasaki, Kengo, et al.
Publicado: (2020)

Ketone body therapy with D/L-β-hydroxybutyric acid solution in severe MADD
por: Fischer, Tobias, et al.
Publicado: (2019)

Measurement of blood acetoacetate and β-hydroxybutyrate in an automatic analyser
por: Galán, Amparo, et al.
Publicado: (2001)

Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension
por: Chakraborty, Saroj, et al.
Publicado: (2018)

Ketone body β-hydroxybutyrate is an autophagy-dependent vasodilator
por: McCarthy, Cameron G., et al.
Publicado: (2021)

β-Hydroxybutyrate as an epigenetic modifier: Underlying mechanisms and implications
por: He, Yanqiu, et al.
Publicado: (2023)

Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model
por: Sun, Wei, et al.
Publicado: (2022)

Microfluidic biosensor for β-Hydroxybutyrate (βHBA) determination of subclinical ketosis diagnosis
por: Weng, Xuan, et al.
Publicado: (2015)

β-Hydroxybutyrate Elicits Favorable Mitochondrial Changes in Skeletal Muscle
por: Parker, Brian A., et al.
Publicado: (2018)

β-hydroxybutyrate and its metabolic effects on age-associated pathology
por: Han, Young-Min, et al.
Publicado: (2020)

Cardioprotective Roles of β-Hydroxybutyrate Against Doxorubicin Induced Cardiotoxicity
por: Liu, Yihai, et al.
Publicado: (2021)

β-hydroxybutyrate enhances bovine neutrophil adhesion by inhibiting autophagy
por: He, Jiyuan, et al.
Publicado: (2023)

Ketone body β-hydroxybutyrate (BHB) preserves mitochondrial bioenergetics
por: Llorente-Folch, I., et al.
Publicado: (2023)

Tau Clearance Mechanisms and Their Possible Role in the Pathogenesis of Alzheimer Disease
por: Chesser, Adrianne S., et al.
Publicado: (2013)

D-beta-hydroxybutyrate extends lifespan in C. elegans
por: Edwards, Clare, et al.
Publicado: (2014)

D-ß-hydroxybutyrate: an anti-aging ketone body
por: Edwards, Clare, et al.
Publicado: (2015)

Neuroprotection and neuroregeneration triggered through the FUS-induced opening of the blood-brain barrier in a Parkinson’s mouse model
por: Konofagou, Elisa, et al.
Publicado: (2015)

Exogenous d‐β‐hydroxybutyrate lowers blood glucose in part by decreasing the availability of L‐alanine for gluconeogenesis
por: Soto‐Mota, Adrian, et al.
Publicado: (2021)

Parkinson’s disease: animal models and dopaminergic cell vulnerability
por: Blesa, Javier, et al.
Publicado: (2014)

Diverging in vitro inflammatory responses toward Streptococcus uberis in mouse macrophages either preconditioned or continuously treated with β-hydroxybutyrate
por: Swartz, T.H., et al.
Publicado: (2021)

ß-Hydroxybutyrate Improves Mitochondrial Function After Transient Ischemia in the Mouse
por: Lehto, Alina, et al.
Publicado: (2022)

The Modification of Poly(3-Hydroxybutyrate-co-4-hydroxybutyrate) by Melt Blending
por: Jo, Minki, et al.
Publicado: (2022)

Fed-Batch Synthesis of Poly(3-Hydroxybutyrate) and Poly(3-Hydroxybutyrate-co-4-Hydroxybutyrate) from Sucrose and 4-Hydroxybutyrate Precursors by Burkholderia sacchari Strain DSM 17165
por: Miranda de Sousa Dias, Miguel, et al.
Publicado: (2017)

Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults
por: Hasegawa, Koichi, et al.
Publicado: (2016)

Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine
por: Chen, Jianfang, et al.
Publicado: (2013)

β-Hydroxybutyrate Oxidation Promotes the Accumulation of Immunometabolites in Activated Microglia Cells
por: Benito, Adrian, et al.
Publicado: (2020)

Antiepileptic effects of exogenous β-hydroxybutyrate on kainic acid-induced epilepsy
por: Si, Jianping, et al.
Publicado: (2020)

β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer’s disease pathology
por: Shippy, Daniel C., et al.
Publicado: (2020)

Lipid Catabolism in Starved Yak Is Inhibited by Intravenous Infusion of β-Hydroxybutyrate
por: Zou, Huawei, et al.
Publicado: (2020)

β-Hydroxybutyrate in Cardiovascular Diseases : A Minor Metabolite of Great Expectations
por: Wei, Shao, et al.
Publicado: (2022)

Engineering Escherichia coli for Poly-β-hydroxybutyrate Production from Methanol
por: Wang, Jiaying, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_u2hpegbrsill635u18pop8l3b7