Motor Deficits and Decreased Striatal Dopamine Receptor 2 Binding Activity in the Striatum-Specific Dyt1 Conditional Knockout Mice

DYT1 early-onset generalized dystonia is a hyperkinetic movement disorder caused by mutations in DYT1 (TOR1A), which codes for torsinA. Recently, significant progress has been made in studying pathophysiology of DYT1 dystonia using targeted mouse models. Dyt1 ΔGAG heterozygous knock-in (KI) and Dyt1...

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Detalles Bibliográficos
Autores principales: Yokoi, Fumiaki, Dang, Mai Tu, Li, Jianyong, Standaert, David G., Li, Yuqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171455/
https://www.ncbi.nlm.nih.gov/pubmed/21931745
http://dx.doi.org/10.1371/journal.pone.0024539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171455/
https://www.ncbi.nlm.nih.gov/pubmed/21931745
http://dx.doi.org/10.1371/journal.pone.0024539

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