Gefitinib Induces Epidermal Growth Factor Receptor Dimers Which Alters the Interaction Characteristics with (125)I-EGF

The tyrosine kinase inhibitor gefitinib inhibits growth in some tumor types by targeting the epidermal growth factor receptor (EGFR). Previous studies show that the affinity of the EGF-EGFR interaction varies between hosting cell line, and that gefitinib increases the affinity for some cell lines. I...

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Detalles Bibliográficos
Autores principales: Björkelund, Hanna, Gedda, Lars, Barta, Pavel, Malmqvist, Magnus, Andersson, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171474/
https://www.ncbi.nlm.nih.gov/pubmed/21931838
http://dx.doi.org/10.1371/journal.pone.0024739

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171474/
https://www.ncbi.nlm.nih.gov/pubmed/21931838
http://dx.doi.org/10.1371/journal.pone.0024739

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