Influence of mild and moderate hepatic impairment on axitinib pharmacokinetics

Objective: To evaluate the effects of hepatic impairment on the pharmacokinetics and safety of a single, oral axitinib dose in subjects with mild or moderate hepatic impairment. Methods: In this phase I, open-label, parallel-group study, a total of 24 subjects with either normal hepatic function (n ...

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Detalles Bibliográficos
Autores principales: Tortorici, Michael A., Toh, Melvin, Rahavendran, S. V., LaBadie, Robert R., Alvey, Christine W., Marbury, Thomas, Fuentes, Ernesto, Green, Matthew, Ni, Grace, Hee, Brian, Pithavala, Yazdi K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Phase I Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171651/
https://www.ncbi.nlm.nih.gov/pubmed/20596748
http://dx.doi.org/10.1007/s10637-010-9477-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171651/
https://www.ncbi.nlm.nih.gov/pubmed/20596748
http://dx.doi.org/10.1007/s10637-010-9477-4

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